Metastatic Breast Cancer Treatment Drug: ABRAXANE for Injectable Suspension
For US Residents Only

 

About Breast Cancer & Chemotherapy


Black Box Warning

ABRAXANE is a prescription medicine used to treat breast cancer that has spread to other parts of the body after treatment with certain other medicines has not worked.

ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin bound) is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated.

There are many different types of breast cancer. Likewise, there are many different ways of treating breast cancer, depending on the type of cancer, how far it has progressed, and personal decisions made by women and their health care professionals. This part of ABRAXANE.com provides an overview of these topics—please talk to your doctor to learn more. You can also visit other helpful resources on the Web to further explore these topics.

Click here for a list of online resources.

To learn more about breast cancer and chemotherapy, click on the links below:

About breast cancer tumors

The body is made up of billions of cells that form tissue and organs. Cells are replaced on a regular basis, allowing each organ to continue to function normally. During this process, cells that die are replaced by new cells. Occasionally, cells are replaced by abnormal cells that grow in an uncontrolled way. As a result, there is an abnormal growth or lump of cells that form a tumor.

There are two kinds of breast tumors: noncancerous (benign) tumors and cancerous (malignant) tumors. Benign breast tumors are not cancerous and do not spread outside the breast in which they appear. Malignant breast tumors are cancerous and are made up of cells that can spread from the breast to other parts of the body.

There are several different types of breast cancer. In many cases, breast cancer starts in the ducts or lobules of the breast (where milk can be produced). In the early stages of breast cancer, breast tumors found in these ducts are called "in situ," meaning that they are in one location and are noninvasive. Invasive breast cancer means that the cancerous breast tumor has broken through the wall of the ducts or lobules and spread to other parts of the body.


Illustration courtesy of the National Cancer Institute

Treatment will vary depending on the type of breast cancer, so it is important to have a thorough medical examination to determine exactly which type is present. For more information about breast tumors, visit our Online Information page.

Back to top

About metastatic breast cancer

Some tumors are benign, meaning that they are not cancerous and will not spread beyond the breast into other organs. Malignant breast tumors are cancerous and are made up of cells that can spread from the breast to other parts of the body. Because of their ability to spread and grow in other organs, malignant breast tumors can interfere with normal body function and can be life-threatening.

Breast cancer cells that metastasize, or break away from the main malignant tumor, can travel to other parts of the body, such as the bones, liver, lungs, or brain. The blood and lymph are body fluids that can carry these cancer cells from the main tumor to other parts of the body.

ABRAXANE® is used to treat tumors that have spread to other parts of the body.

ABRAXANE is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated.

For more information about metastatic breast cancer, visit our Online Information page.

Back to top

Learning about chemotherapy

Chemotherapy is the use of drugs to destroy cancer cells, including those that have spread to areas other than the breast.

The drugs used in chemotherapy are called cytotoxic drugs because they kill cells. The drugs circulate throughout the body in the bloodstream, killing both cancer cells and some healthy cells. Chemotherapy drugs are carefully controlled in both dosage and frequency so that cancer cells are destroyed while minimizing the risk to healthy cells. Several different types of cytotoxic agents are used to treat breast cancer.

The choice of chemotherapy is different for each person and depends on what kind of cancer a person has, how large the tumor is, and how far it has spread. You and your doctor will decide whether chemotherapy is right for you and which drugs are most appropriate given your type and stage of breast cancer.

For more information about chemotherapy, visit our Online Information page.

Back to top

 

WARNING: ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) should be given under the care of a doctor experienced with cancer therapy in a health care facility that is capable of managing possible complications.

ABRAXANE should not be given to patients who have dangerously low white blood counts because of the risk for serious infections. Frequent blood tests are used to check white blood cell count during therapy with ABRAXANE.

An albumin form of paclitaxel may behave differently in the body than other paclitaxel medications. ABRAXANE SHOULD NOT BE SUBSTITUTED FOR OR WITH OTHER PACLITAXEL FORMULATIONS.

IMPORTANT SAFETY INFORMATION

One of the more important side effects associated with chemotherapy is a decrease in the number of infection-fighting white blood cells (neutrophils) called “neutropenia”. ABRAXANE should not be given to patients with dangerously low white blood cell counts because of the risk for serious infections. Your doctor will schedule blood tests to check your white blood cell count (absolute neutrophil count (ANC)) during therapy with ABRAXANE. Tell your doctor if you have a fever or notice any other signs of an infection.

Women should avoid becoming pregnant while being treated with ABRAXANE. Tell your doctor if you are pregnant, if you become pregnant, or you plan to become pregnant while taking ABRAXANE. Nursing a baby while taking ABRAXANE is not recommended because the drug may be present in breast milk. Men should be advised not to father a child while receiving treatment with ABRAXANE.

ABRAXANE contains albumin (human), a derivative of human blood.

The most important side effects have included hair loss, infections due to low white blood cell count, numbness, tingling or burning in the hands or feet, fatigue and weakness, low red blood cell count, mouth or lip sores, joint and muscle pain, stomach upset and diarrhea, heart and blood vessel (cardiovascular) effects and irritation at the injection site.

Numbness, tingling, or burning in the hands and feet (neuropathy) occurs with ABRAXANE and other paclitaxel medications. Be sure to tell your doctor if you experience these symptoms. Your doctor may interrupt treatment and restart at a lower dose after symptoms improve.

Other side effects have included blurred vision or eye irritation, fluid retention, liver and kidney dysfunction, low platelet counts, and allergic reactions (which in rare cases were severe). Tell your doctor about any side effects that bother you.

Your ability to drive and use machines may be limited by side effects such as: fatigue, lethargy and malaise.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

The information on this site is intended for US residents only.

ABRAXANE is a registered
trademark of Abraxis BioScience, LLC.

All Abraxis BioScience, LLC.
corporate names, names of services,
and names of products referred to herein
are trade names, service marks, and/or
trademarks that are owned by or licensed
to Abraxis BioScience, its divisions or its
affiliates, unless otherwise noted.

©2009 Abraxis BioScience, LLC.
All Rights Reserved. AB 1399 10/09

Abraxis

WARNING: ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension) (albumin-bound) should be given under the care of a doctor experienced with cancer therapy in a health care facility that is capable of managing possible complications.

ABRAXANE should not be given to patients who have dangerously low white blood counts because of the risk for serious infections. Frequent blood tests are used to check white blood cell count during therapy with ABRAXANE.

An albumin form of paclitaxel may behave differently in the body than other paclitaxel medications. ABRAXANE SHOULD NOT BE SUBSTITUTED FOR OR WITH OTHER PACLITAXEL FORMULATIONS.

IMPORTANT SAFETY INFORMATION

One of the more important side effects associated with chemotherapy is a decrease in the number of infection-fighting white blood cells (neutrophils) called “neutropenia”. ABRAXANE should not be given to patients with dangerously low white blood cell counts because of the risk for serious infections. Your doctor will schedule blood tests to check your white blood cell count (absolute neutrophil count (ANC)) during therapy with ABRAXANE. Tell your doctor if you have a fever or notice any other signs of an infection.

Women should avoid becoming pregnant while being treated with ABRAXANE. Tell your doctor if you are pregnant, if you become pregnant, or you plan to become pregnant while taking ABRAXANE. Nursing a baby while taking ABRAXANE is not recommended because the drug may be present in breast milk. Men should be advised not to father a child while receiving treatment with ABRAXANE.

ABRAXANE contains albumin (human), a derivative of human blood.

The most important side effects have included hair loss, infections due to low white blood cell count, numbness, tingling or burning in the hands or feet, fatigue and weakness, low red blood cell count, mouth or lip sores, joint and muscle pain, stomach upset and diarrhea, heart and blood vessel (cardiovascular) effects and irritation at the injection site.

Numbness, tingling, or burning in the hands and feet (neuropathy) occurs with ABRAXANE and other paclitaxel medications. Be sure to tell your doctor if you experience these symptoms. Your doctor may interrupt treatment and restart at a lower dose after symptoms improve.

Other side effects have included blurred vision or eye irritation, fluid retention, liver and kidney dysfunction, low platelet counts, and allergic reactions (which in rare cases were severe). Tell your doctor about any side effects that bother you.

Your ability to drive and use machines may be limited by side effects such as: fatigue, lethargy and malaise.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088.

The information on this site is intended for US residents only.

ABRAXANE is a registered trademark of Abraxis BioScience, LLC. Abraxis Oncology® is a division of Abraxis BioScience, LLC.

All Abraxis BioScience, LLC. corporate names, names of services, and names of products referred to herein are trade names, service marks, and/or trademarks that are owned by or licensed to Abraxis BioScience, its divisions or its affiliates, unless otherwise noted.

©2009 Abraxis BioScience, LLC.
All Rights Reserved. AB 1399   10/09
(Site updated 01/09)

Abraxis